Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.3K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visible-Light-Induced Release of Carbon Monoxide: Multifunctionally Treatment for Dry Eye Disease.

Nano letters·2026
Same author

Whole-Exome Analysis Identifies Candidate Genes Associated With Diabetic Retinopathy.

Investigative ophthalmology & visual science·2026
Same author

2-Aminoadipic Acid mediates the association between BMI and Lipids: Evidence from the CLSA and BHS Cohorts and Mendelian randomization.

American journal of preventive cardiology·2026
Same author

Targeting SYK to alleviate MDSC-driven immunosuppression and augment anti-PD1 efficacy.

Science China. Life sciences·2026
Same author

Comprehensive genomic and computational insights into Brucella suis: pan-genome analysis, evolutionary perspectives, and in-silico vaccine design.

BMC genomics·2026
Same author

Colocalization of eQTLs With Type 2 Diabetes and Glycemic Traits Using Whole-Genome Sequences in Diverse Populations From the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program.

Diabetes·2026

Related Experiment Video

Updated: Dec 28, 2025

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

1.4K

The BDNF Val66Met Polymorphism, Regular Exercise, and Cognition: A Systematic Review.

Tingting Liu1, Hongjin Li2, Joseph P Colton1

  • 1University of Arkansas Eleanor Mann School of Nursing, Fayetteville, AR, USA.

Western Journal of Nursing Research
|February 21, 2020
PubMed
Summary

Research on the BDNF Val66Met polymorphism, exercise, and cognition is limited. While some memory benefits may exist for Val/Val homozygotes with exercise, more data is needed for other cognitive functions.

Keywords:
brain-derived neurotrophic factorcognitionexercisegene-environment interaction

More Related Videos

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD
06:09

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Published on: February 2, 2017

7.1K
Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation
04:48

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

Published on: April 18, 2025

952

Related Experiment Videos

Last Updated: Dec 28, 2025

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

1.4K
Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD
06:09

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Published on: February 2, 2017

7.1K
Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation
04:48

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

Published on: April 18, 2025

952

Area of Science:

  • Neuroscience
  • Genetics
  • Exercise Science

Background:

  • The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences neuronal plasticity.
  • Regular exercise is known to impact cognitive function.
  • Understanding the interplay between BDNF genotype, exercise, and cognition is crucial.

Purpose of the Study:

  • To systematically review and synthesize existing research on the association between the BDNF Val66Met polymorphism, regular exercise, and cognitive performance in humans.
  • To identify gaps in the current literature and guide future research directions.

Main Methods:

  • Systematic literature search of PubMed, CINAHL, and Web of Science databases.
  • Inclusion criteria: human subjects, English language, peer-reviewed articles published between 2009 and 2019.
  • Eight relevant studies were included in the final review.

Main Results:

  • Limited evidence suggests potential memory benefits associated with higher exercise levels in Val/Val homozygotes compared to Met carriers.
  • Findings regarding attention, information processing speed, executive function, and global cognition were inconsistent or sparse.
  • The current body of evidence does not permit firm conclusions on these relationships.

Conclusions:

  • More high-quality clinical trials are required to elucidate the complex interactions between the BDNF Val66Met polymorphism, exercise, and cognitive outcomes.
  • Further research should focus on specific cognitive domains and well-defined exercise interventions.