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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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Published on: February 2, 2021

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Long-Term Outcomes in Patients with Acute Kidney Injury

Rebecca A Noble1,2, Bethany J Lucas1,2, Nicholas M Selby1,2

  • 1Centre for Kidney Research and Innovation, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom; and.

Clinical Journal of the American Society of Nephrology : CJASN
|February 21, 2020
PubMed

Insights

Long-term complications following acute kidney injury (AKI) are increasingly recognized. This review examines outcomes like mortality, chronic kidney disease (CKD), and cardiovascular events, highlighting unmet clinical needs.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Clinical Research

Background:

  • Long-term consequences of acute kidney injury (AKI) are gaining attention.
  • Associations between AKI and adverse outcomes like mortality and chronic kidney disease (CKD) are established.
  • Optimal care and interventions for AKI sequelae remain an unmet clinical need.

Purpose of the Study:

  • To review current understanding of long-term outcomes after AKI.
  • To identify knowledge gaps in the long-term sequelae of AKI.
  • To cover mortality, CKD, ESKD, proteinuria, cardiovascular events, recurrent AKI, and readmission.

Main Methods:

  • Systematic review of published data.
  • Analysis of studies reporting long-term outcomes post-AKI.
  • Synthesis of evidence on mortality, CKD progression, and other adverse events.

Main Results:

  • AKI is associated with increased long-term mortality.
  • Significant risk of developing chronic kidney disease (CKD) post-AKI.
  • Established links between AKI and cardiovascular events and recurrent AKI.

Conclusions:

  • Long-term sequelae of AKI represent a significant clinical challenge.
  • Further research is needed to address knowledge gaps in AKI outcomes.
  • Improved interventions and care strategies are crucial for managing AKI survivors.

Keywords:
acute kidney injuryattentioncardiovascular diseaseschronic kidney failurechronic renal insufficiencyclinical nephrologydisease progressionhumansincidenceoutcomespatient readmissionprogression of renal failureproteinuriarenal injury

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