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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

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A CMOS MEMS-based Membrane-Bridge Nanomechanical Sensor for Small Molecule Detection.

Yi-Kuang Yen¹, Chao-Yuan Chiu²

¹Department of Mechanical Engineering, National Taipei University of Technology, Taipei, 106, Taiwan. ykyen@ntut.edu.tw.

Scientific Reports

|February 21, 2020

Summary

A new CMOS BioMEMS sensor offers a sensitive, portable, and affordable method for detecting small molecule drugs like phenytoin in blood. This membrane-bridge sensor provides rapid and reliable monitoring within therapeutic ranges.

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Area of Science:

Biomedical Engineering
Nanotechnology
Analytical Chemistry

Background:

Small molecule compounds require sensitive detection due to their potent physiological effects.
Current methods for blood small molecule analysis are often impractical for point-of-care use, being inconvenient, expensive, and time-consuming.

Purpose of the Study:

To develop a sensitive, portable, and cost-effective sensor for small molecule detection.
To demonstrate the efficacy of a novel complementary metal-oxide-semiconductor bio-microelectromechanical system (CMOS BioMEMS) based membrane-bridge (MB) sensor for phenytoin concentration monitoring.

Main Methods:

Design and fabrication of a piezoresistive membrane-bridge (MB) sensor on a CMOS BioMEMS platform.
Integration of on-chip thermal effect elimination and a reaction tank for disposable use.
Testing the sensor's performance in detecting phenytoin across various concentrations (5-100 μg/mL).

Main Results:

The MB sensor exhibited a 2-fold increase in signal response compared to microcantilever sensors.
Achieved a limit of detection of 4.06 ± 0.15 μg/mL for phenytoin.
Demonstrated a linear detection range of 5-100 μg/mL, suitable for therapeutic drug monitoring.

Conclusions:

The developed nano-mechanical MB sensor is specific, sensitive, robust, affordable, and reproducible.
The sensor's design, featuring thermal compensation and a compact chip carrier, is ideal for disposable applications.
This CMOS BioMEMS sensor represents a promising advancement for practical small molecule detection in clinical settings.