Related Experiment Video
Updated: Dec 28, 2025
08:17
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
Published on: February 27, 2018
16.9K
Dexmedetomidine May Reduce IL-6 Level and the Risk of Postoperative Cognitive Dysfunction in Patients After Surgery:
Daoyun Lei1, Yeqin Sha2, Shuang Wen2
1Department of Anesthesiology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, China.
Dose-Response : a Publication of International Hormesis Society
|February 21, 2020
Summary
Dexmedetomidine (DEX) reduces the risk of postoperative cognitive dysfunction (POCD). DEX use also improved cognitive scores and lowered inflammation markers like NSE and IL-6.
Area of Science:
- Anesthesiology
- Neuroscience
- Critical Care Medicine
Background:
- Postoperative cognitive dysfunction (POCD) is a common complication.
- The efficacy of dexmedetomidine (DEX) in preventing POCD requires further confirmation.
Purpose of the Study:
- To evaluate the effect of DEX on the incidence of POCD.
- To assess DEX's impact on cognitive function and inflammatory markers post-surgery.
Main Methods:
- A meta-analysis was conducted.
- Data on POCD incidence, Mini-Mental State Examination scores, neuron-specific enolase (NSE), and interleukin-6 (IL-6) levels were analyzed.
Main Results:
- DEX significantly reduced POCD incidence on postoperative days 1 and 7 (OR: 0.41-0.53).
- Mini-Mental State Examination scores were higher in the DEX group.
- NSE and IL-6 levels were lower in the DEX group on postoperative day 1.
Conclusions:
- DEX use is associated with a lower risk of POCD.
- Reduced NSE and IL-6 levels suggest potential benefits for long-term cognitive function and anti-inflammation.
Related Concept Videos
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
431
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
431
01:22Stages of General Anesthesia
1.3K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
1.3K
01:24Parenteral Anesthetics: Overview
512
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
512
01:24General Anesthesia: Overview
506
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
506
01:23Sedatives and Hypnotics: Overview
1.2K
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
1.2K
01:28Cardiomyopathy VII: Pre and Post Operative Nursing Management
215
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
215