Related Experiment Video
Updated: Dec 28, 2025
07:25
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
7.3K
Will we need novel combinations to cure HBV infection?
1Kings College Hospital, London, UK.
Summary
Chronic hepatitis B requires long-term nucleoside analogue therapy for cirrhosis and cancer risk reduction. Achieving a functional cure, defined by HBsAg loss off treatment, remains uncommon, necessitating new combination therapies.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- Chronic hepatitis B (CHB) is a major cause of liver cirrhosis and hepatocellular carcinoma.
- Current nucleoside analogue therapies require maintenance to suppress the virus, as functional cure (HBsAg loss) is rare.
Purpose of the Study:
- To review current and investigational strategies for achieving a functional cure for CHB.
- To explore the potential of combination therapies and immune modulation for HBV treatment.
Main Methods:
- Review of current literature on nucleoside analogue therapy for CHB.
- Analysis of ongoing clinical trials investigating novel antiviral agents and combination therapies.
- Discussion of mechanisms targeting HBV replication, cccDNA, and immune responses.
Main Results:
- Investigational agents aim to inhibit HBV replication, deplete cccDNA, or modulate the immune system.
- Combination therapies are being explored for synergistic effects to achieve HBsAg loss.
- Nucleoside analogue-suppressed patients are key participants in current trials.
Conclusions:
- Achieving a functional cure for CHB likely requires combination therapy with novel agents and immune modulators.
- Finite, safe, and highly effective treatments are needed to broaden treatment candidacy.
- Therapeutic withdrawal remains challenging due to risks of hepatitis flares and decompensation.
More Related Videos
05:55Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System
Published on: December 21, 2019
7.1K
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
2.6K
Related Concept Videos
01:10Retrovirus Life Cycles
49.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.0K
01:27Combined Effects of Drugs: Synergism
6.6K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
6.6K
02:50Combination Therapies and Personalized Medicine
5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
01:29Viruses with RNA Genomes
613
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
613
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
960
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
960