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Recognition and management of the gastrointestinal and hepatic immune-related adverse events

Bei Tan1, Yue Li1, Yan Xu2

  • 1Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China.

Asia-Pacific Journal of Clinical Oncology
|February 21, 2020
PubMed

Immunotherapy is revolutionizing the treatment paradigm for a broad spectrum of malignancies. However, the immune checkpoint inhibitors also cause a unique set of toxicities. In the digestive system, this has consisted for the most part as colitis and hepatotoxicity, but also include less-common manifestations. Baseline screening, early identification, timely diagnosis, rapid and adequate treatment can significantly minimize the toxicity of immunotherapy and improve prognosis. This article provides a comprehensive review of gastrointestinal and hepatic immune-related toxicities, including incidence, mechanism, clinical manifestation, diagnosis, treatment, and guidelines for resumption of immune checkpoint inhibitor therapy.

Keywords:
gastrointestinalhepaticimmune checkpoint inhibitorimmune-related adverse eventimmunotherapy

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