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Targeting Age-Related Pathways in Heart Failure

Haobo Li1, Margaret H Hastings1, James Rhee1,2

  • 1From the Corrigan Minehan Heart Center, Massachusetts General Hospital, Harvard Medical School, Boston (H.L., M.H.H., J.R., L.E.T., J.D.R., A.R.).

Circulation Research
|February 21, 2020
PubMed

Insights

Cardiac aging leads to heart failure, but exercise reveals new pathways to combat this decline. Research highlights exercise as a platform for discovering novel therapeutic targets for age-related heart disease.

Area of Science:

  • Cardiology
  • Gerontology
  • Molecular Biology

Background:

  • Aging causes cardiac structural and functional decline, increasing heart failure risk.
  • The growing elderly population heightens the urgency for interventions against age-related cardiac issues.
  • Current understanding of cardiac aging and general aging processes remains limited.

Purpose of the Study:

  • To review recent findings on molecular mechanisms underlying age-related heart failure.
  • To highlight exercise as a key experimental model for identifying therapeutic targets.
  • To address the need for novel interventions in chronic cardiovascular disease.

Main Methods:

  • Literature review of recent studies on cardiac aging.
  • Analysis of molecular pathways involved in age-related cardiac decline.
  • Examination of exercise interventions and their effects on cardiac health.

Main Results:

  • Novel pathological and cardioprotective pathways associated with aging have been identified.
  • Exercise has emerged as a significant factor in understanding and potentially preventing cardiac aging.
  • Specific molecular mechanisms driving age-related heart failure are being elucidated.

Conclusions:

  • Understanding the molecular basis of cardiac aging is crucial for developing effective treatments.
  • Exercise provides a valuable platform for discovering new therapeutic targets for age-related heart failure.
  • Further research into exercise-mediated cardioprotection can lead to novel interventions for chronic heart disease.

Keywords:
agingepigeneticsexerciseheart failuresenescence

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