Metabolic Characteristics and Diagnostic Contribution of ¹⁸F-FDG PET/CT in Gastric Carcinomas

The aim of this study was to evaluate ¹⁸F-fluoro-2-deoxy-glucose (FDG) uptake patterns in primary tumors and metastatic lesions, and also to assess the diagnostic contribution of positron emission tomography/computed tomography (PET/CT) in the initial staging of gastric cancer (GC).

The total number of 341 patients with GC were included in this study. All ¹⁸F-FDG PET/CT imagings were performed for initial staging. The maximum standardized uptake value (SUV_max) of primary tumor, obtained from ¹⁸F-FDG PET/CT imaging was compared between subtypes of GC.

Mean SUV_max of 339 patients’ primary tumor was 12.9±8.6. The highest mean SUV_max was detected in patients with medullary subtype GC (17.8±9.9) while the lowest mean SUV_max (9.7±7.6) was seen in signet ring cell carcinoma (SRCC). The primary mean SUV_max was found statistically higher in tubular adenocarcinoma (TAC) group than SRCC group (p<0.001). Higher SUV_max values were found statistically significantly correlated with advanced age (aged ≥60) and increased tumor size (>3 cm) in patients with TAC (p=0.03). Primary tumor SUV_max was found statistically higher in regional lymph node (RLN) positive patients than in RLN negative patients in TAC and SRCC groups (p<0.001 and p=0.012, respectivelly). Also, in patients with SRCC, SUV_max was significantly higher in the distant metastatic group than in the group without metastasis (p=0.025).

Increased primary tumor SUV_max was associated with some of clinical parameters such as age and RLN metastasis in patients with TAC. However, there was no relationship between distant metastatic state and primary tumor ¹⁸F-FDG uptake in TAC. However, high SUV_max of primary tumor in SRCC was associated with regional and distant metastasis, and primary tumor ¹⁸F-FDG uptake may be a prognostic value for this subgroup.