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Ret Receptor Has Distinct Alterations and Functions in Breast Cancer

Albana Gattelli1,2, Nancy E Hynes3,4, Ignacio E Schor5,6

  • 1CONICET-UBA, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Ciudad Universitaria, C1428EGA CABA, Buenos Aires, Argentina. albanaga@fbmc.fcen.uba.ar.

Journal of Mammary Gland Biology and Neoplasia
|February 22, 2020
PubMed

Insights

Ret alterations are crucial in breast cancer development. Targeting the Ret pathway, through genetic changes or overexpression, may offer new therapeutic strategies and biomarkers for recurrence.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ret receptor tyrosine kinase (RTK) is a proto-oncogene implicated in various cancers.
  • Recent studies highlight Ret's significant role in breast cancer, particularly in estrogen receptor-positive subtypes.
  • A comprehensive understanding of Ret alterations in breast cancer is currently lacking.

Purpose of the Study:

  • To consolidate current knowledge on Ret alterations and their effects in breast cancer.
  • To analyze Ret changes across different breast cancer subtypes and their role in progression.
  • To explore the involvement of Ret signaling network partners in breast cancer pathogenesis.

Main Methods:

  • Review of experimental evidence from basic research.
  • Analysis of pre-clinical studies focusing on Ret alterations.
  • Integration of data on Ret genetic changes and overexpression.

Main Results:

  • Ret alterations, including genetic changes and overexpression, are observed in various breast cancer subtypes.
  • Ret signaling pathways and its network partners play a role in breast cancer progression.
  • Ret alterations show potential as biomarkers for predicting recurrence.

Conclusions:

  • Defining shared molecular features of Ret-altered tumors is essential for targeted therapy development.
  • Targeting the Ret pathway presents a promising future therapeutic strategy for breast cancer.
  • Further research into Ret alterations may lead to novel treatment options and improved patient outcomes.
Keywords:
Breast tumorsER +Endocrine resistanceRearrangementsRet

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