Related Experiment Video
Updated: Dec 28, 2025
Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
Transcatheter Device Closure of Perimembranous Ventricular Septal Defect in Pediatric Patients: Long-Term Outcomes
Jayal Hasmukhbhai Shah1, Sanket Pravinchandra Saraiya1, Tushar Sudhakarrao Nikam1
1Department of Cardiology, U N Mehta Institute of Cardiology and Research Center, Civil Hospital Campus, Ahmedabad, Gujarat, India.
Insights
Transcatheter device closure for perimembranous ventricular septal defects (VSD) is safe and effective in pediatric patients. This minimally invasive approach offers a viable alternative to surgery with excellent long-term outcomes.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Interventional Cardiology
Background:
- Perimembranous ventricular septal defects (VSD) are common congenital heart abnormalities.
- Surgical closure has been the traditional treatment, but carries risks.
- Transcatheter device closure offers a less invasive alternative.
Purpose of the Study:
- To evaluate the long-term safety and efficacy of transcatheter device closure for perimembranous VSD in children.
- To assess the procedural success rates and complication profile.
- To compare outcomes with historical surgical data.
Main Methods:
- Prospective study of 376 pediatric patients with perimembranous VSD undergoing transcatheter closure.
- Transthoracic echocardiography and electrocardiogram performed pre- and post-procedure.
- Annual follow-up evaluations including echocardiography and electrocardiogram for extended periods.
Main Results:
- Successful closure achieved in 98.93% of patients.
- No mortality reported.
- Rhythm disturbances, including complete atrioventricular block, occurred in 8.5% of patients.
Conclusions:
- Transcatheter closure of perimembranous VSD is a safe and effective procedure in experienced centers.
- It demonstrates minimal morbidity and no mortality, making it a suitable alternative to surgery for selected pediatric patients.
- Long-term follow-up confirms the durability and safety of this interventional approach.
Aims:
The aim of this study is to evaluate the safety and efficacy of transcatheter device closure of perimembranous ventricular septal defects in pediatric patients at long-term follow-up.
Materials And Methods:
We prospectively studied 376 patients with perimembranous VSDs between September 2008 and December 2015 who underwent percutaneous closure at our center. Transthoracic echocardiography (TTE) and electrocardiogram were done before and after the procedure in all the patients. All patients were subjected to follow-up evaluation at 1, 3, 6, 12 months, and annually thereafter with TTE and electrocardiogram.
Results:
A total of 376 patients (210 males and 166 females) underwent transcatheter closure of perimembranous VSD. Mean age of patients was 8.67 ± 3.02 (range 3-18 years) and mean weight was 21.15 ± 8.31 (range 8-65 kg). The procedure was carried out successfully in 98.93% of patients with no reported mortality. Rhythm disturbances occurred in 8.5% of patients after the procedure which included three cases of complete atrioventricular block.
Conclusion:
This study shows that in experienced hands transcatheter closure of perimembrnous VSD is safe and effective at long-term follow-up. With minimal morbidity and no mortality, the transcatheter is an effective alternative to surgical closure in selected patients.
