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Pediatric Acute Kidney Injury-The Time for Nihilism Is Over

Stuart L Goldstein1

  • 1Center for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Frontiers in Pediatrics
|February 22, 2020
PubMed

Insights

Pediatric acute kidney injury (AKI) research is advancing, shifting away from decades of nihilism. Recent symposiums highlight progress in diagnosing and treating AKI in children, driven by increased investment.

Area of Science:

  • Pediatric Nephrology
  • Renal Medicine
  • Critical Care Medicine

Background:

  • Historically, a lack of progress in reducing acute kidney injury (AKI) rates in hospitalized patients fostered nihilism in the field.
  • Children with AKI represent an underserved "orphan" population, lacking specific diagnostics and therapeutics.
  • The 3rd International Symposium on Acute Kidney Injury in Children convened to address these challenges.

Purpose of the Study:

  • To showcase advancements in the diagnosis and treatment of pediatric AKI.
  • To identify persistent barriers hindering progress in pediatric AKI care.
  • To foster a shift from nihilism to optimism in the pediatric AKI field.

Main Methods:

  • The 3rd International Symposium on Acute Kidney Injury in Children served as a platform for discussion and presentation.
  • Review of progress in pediatric AKI since the 2nd International Symposium in 2016.
  • Analysis of outcomes attributed to investments from federal agencies, private foundations, and corporate sponsors.

Main Results:

  • Significant advancements in the diagnosis and treatment of pediatric AKI were demonstrated.
  • Positive outcomes linked to increased investment in pediatric AKI research were highlighted.
  • Key barriers to advancing care for children with AKI were identified.

Conclusions:

  • The symposium provided evidence that progress is being made in pediatric AKI.
  • Increased funding from diverse sources is yielding positive results.
  • The era of nihilism in pediatric AKI is drawing to a close, replaced by a focus on continued advancement.

Keywords:
acute kidney injurybiomarkerschildrennihilismrenal replacement therapies

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