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Recent Progress in NIR-II Contrast Agent for Biological Imaging.

Jie Cao1,2,3, Binling Zhu3,4,5, Kefang Zheng2,3

  • 1Fuzhou University Postdoctoral Research Station of Chemical Engineering and Technology, Fuzhou University, Fuzhou, China.

Frontiers in Bioengineering and Biotechnology
|February 22, 2020
PubMed
Summary
This summary is machine-generated.

Second near-infrared (NIR-II) fluorescence bioimaging offers deeper tissue visualization than traditional methods. This review surveys NIR-II contrast agents for improved cancer imaging and medical diagnostics, addressing current challenges.

Keywords:
biological imagingbiomedical applicationscontrast agentsfluorescence imaging technologythe second region near infrared (NIR-II)

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Nanotechnology

Background:

  • Fluorescence imaging provides real-time, sub-cellular resolution for biological and medical applications.
  • Visible light and traditional near-infrared (NIR-I) imaging are limited by shallow penetration depth and tissue autofluorescence.
  • The second near-infrared window (NIR-II, 1000-1700 nm) offers improved signal-to-noise ratio and deeper tissue penetration.

Purpose of the Study:

  • To survey the development of NIR-II imaging contrast agents (probes).
  • To review the applications of NIR-II bioimaging in cancer imaging, medical detection, vascular imaging, and diagnosis.
  • To discuss current challenges and future directions in NIR-II bioimaging.

Main Methods:

  • Literature review of existing research on NIR-II fluorescence probes and their applications.
  • Analysis of the performance of NIR-II bioimaging compared to visible and NIR-I imaging.
  • Discussion of key contrast agents including carbon nanotubes, Ag2S quantum dots, and organic small molecules.

Main Results:

  • NIR-II bioimaging achieves centimeter-scale deep-tissue information with micron-level resolution at millimeter depths.
  • NIR-II imaging significantly improves signal-to-noise ratio, overcoming limitations of NIR-I.
  • Progress in NIR-II probes remains limited, with few reported examples.

Conclusions:

  • NIR-II bioimaging holds significant promise for advancing deep-tissue visualization in medical and biological fields.
  • Development of novel and efficient NIR-II contrast agents is crucial for realizing its full potential.
  • Further research is needed to overcome current challenges and inspire new applications in cancer diagnosis and treatment.