Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

158
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
158
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

299
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
299

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRI-guided detection of knee injuries as a concomitant lesion of femoral shaft fractures: a systematic review and meta-analysis.

EFORT open reviews·2026
Same author

Population-based characterization of left atrial and appendage variations: Prevalence, risk factor associations, and sex-specific morphology.

Journal of cardiovascular computed tomography·2026
Same author

Incidentally Detected Splenomegaly and Risk of Hematologic Cancer and Liver Disease.

JAMA oncology·2026
Same author

Assessing the Efficacy of Ortho GPT: A Comparative Study with Medical Students and General LLMs on Orthopedic Examination Questions.

Bioengineering (Basel, Switzerland)·2025
Same author

The dynamic reconstruction of the medial patellofemoral ligament shows good subjective outcomes but high rates of recurrent instability: a systematic review and meta-analysis.

EFORT open reviews·2025
Same author

Computed Tomography-Based Evaluation of Redo-Transcatheter Aortic Valve Replacement Feasibility for Self-Expanding Valves.

Structural heart : the journal of the Heart Team·2025
Same journal

Risk Stratification in Aortic Stenosis: Exercise Hemodynamics to Refine Risk in Early Cardiac Damage Stages.

European heart journal. Cardiovascular Imaging·2026
Same journal

Reply to the letter: 'multimodality imaging in cardio-oncology: from detection to actionable management to the editor'.

European heart journal. Cardiovascular Imaging·2026
Same journal

Incremental Prognostic Value of Cardiac Magnetic Resonance Beyond Biomarker Staging in Transthyretin Cardiac Amyloidosis.

European heart journal. Cardiovascular Imaging·2026
Same journal

Reference Framework for Implementation of Cardiovascular Imaging in Clinical Trials. A Scientific Statement of the European Association of Cardiovascular Imaging (EACVI) of the ESC.

European heart journal. Cardiovascular Imaging·2026
Same journal

Left atrial intramural hematoma secondary to ethanol infusion of the vein of marshall.

European heart journal. Cardiovascular Imaging·2026
Same journal

CMR Predictors of Liver Cirrhosis by MRI in a National Paediatric Fontan Cohort.

European heart journal. Cardiovascular Imaging·2026
See all related articles

Related Experiment Video

Updated: Dec 28, 2025

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

20.0K

Left ventricular myocardial crypts: morphological patterns and prognostic implications.

Per E Sigvardsen1,2, Michael H C Pham1,2, Jørgen T Kühl1

  • 1Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

European Heart Journal. Cardiovascular Imaging
|February 22, 2020
PubMed
Summary
This summary is machine-generated.

Left ventricular myocardial crypts are common in the general population. These anatomical variations do not appear to increase the risk of major adverse cardiovascular events in the intermediate term.

Keywords:
hypertrophic cardiomyopathyleft ventricular myocardial cryptsmyocardial disease

More Related Videos

Author Spotlight: Developing a Translational Model for Atrial Fibrillation Research Across Species
08:52

Author Spotlight: Developing a Translational Model for Atrial Fibrillation Research Across Species

Published on: November 21, 2023

1.4K
Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

15.3K

Related Experiment Videos

Last Updated: Dec 28, 2025

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

20.0K
Author Spotlight: Developing a Translational Model for Atrial Fibrillation Research Across Species
08:52

Author Spotlight: Developing a Translational Model for Atrial Fibrillation Research Across Species

Published on: November 21, 2023

1.4K
Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

15.3K

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Cardiac Anatomy

Background:

  • Left ventricular (LV) myocardial crypts are subtle markers, often associated with hypertrophic cardiomyopathy.
  • However, their presence in healthy individuals raises questions about their clinical significance and association with adverse outcomes.

Purpose of the Study:

  • To investigate the association between left ventricular myocardial crypts and major adverse cardiovascular events (MACE).
  • To determine if crypt characteristics influence cardiovascular risk.

Main Methods:

  • Contrast-enhanced cardiac computed tomography (CE-CCT) was used to assess myocardial crypts in 10,097 individuals.
  • Crypts were defined by depth (>50% myocardial wall penetration) and analyzed for number, location, shape, penetrance, and volume.
  • Major adverse cardiovascular events (composite of death, myocardial infarction, heart failure, stroke) were tracked over a median follow-up of 4.0 years.

Main Results:

  • Left ventricular myocardial crypts were identified in 9.1% of the study population (1199 crypts in 915 individuals).
  • Individuals with one or multiple crypts showed no statistically significant increased risk for major adverse cardiovascular events compared to those without crypts.
  • No specific crypt characteristic (location, shape, penetrance, volume) was linked to a higher risk of adverse cardiovascular events.

Conclusions:

  • Left ventricular myocardial crypts are a frequent finding in the general population.
  • The presence of myocardial crypts is not associated with an increased risk of intermediate-term major adverse cardiovascular events.