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Recapitulating the Vasculature Using Organ-On-Chip Technology.

Andreas M A O Pollet^1,2, Jaap M J den Toonder^1,2

¹Microsystems, Department of Mechanical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The Netherlands.

Bioengineering (Basel, Switzerland)

|February 23, 2020

Summary

This review explores Vasculature-on-Chip fabrication methods, comparing their ability to replicate complex in vivo vasculature. It highlights the biological relevance and limitations of current engineering approaches for creating vascular networks on a chip.

Keywords:

angiogenesis microfabrication microfluidics organ-on-chip vasculature vasculogenesis

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Area of Science:

Biomedical Engineering
Tissue Engineering
Microfluidics

Background:

The in vivo vasculature is a complex system with intricate biological processes.
Recent advancements offer numerous fabrication possibilities for engineering vessels on a chip.

Purpose of the Study:

To review the biological background of in vivo vasculature.
To evaluate the biological relevance of various Vasculature-on-Chip fabrication methods.
To assess the capabilities and limitations of these methods in recapitulating vascular complexity.

Main Methods:

Review of existing literature on in vivo vasculature.
Analysis of different fabrication techniques for Vasculature-on-Chip.
Comparison of fabrication methods based on biological relevance and recapitulation of in vivo complexity.

Main Results:

Fabrication methods for Vasculature-on-Chip vary significantly in their ability to mimic in vivo conditions.
Each method presents unique advantages and disadvantages.
Recapitulating the intrinsic complexity of the vasculature remains a key challenge.

Conclusions:

Developing in vitro vasculature models is complex.
A comprehensive overview of fabrication methods is provided, emphasizing biological relevance.
Understanding the limitations of current techniques is crucial for future advancements in Vasculature-on-Chip technology.