[Research progress on the relationship between cisplatin ototoxicity and autophagy]

Area of Science:

• Ototoxicity
• Cellular Biology
• Pharmacology

Background:

• Cisplatin is a vital chemotherapy drug for solid tumors.
• Cisplatin treatment frequently causes hearing loss (ototoxicity).
• Current protective measures against cisplatin ototoxicity are limited.

Purpose of the Study:

• To review the connection between cisplatin-induced ototoxicity and autophagy.
• To explore autophagy's role in cisplatin-induced hearing loss.
• To provide a basis for future research on ototoxicity interventions.

Main Methods:

• Literature review of studies on cisplatin ototoxicity.
• Analysis of research linking autophagy to hearing loss.
• Synthesis of current understanding of the relationship.

Main Results:

• Autophagy is implicated in the mechanism of cisplatin-induced ototoxicity.
• Evidence suggests autophagy plays a role throughout the process of hearing loss.
• This review consolidates existing knowledge on the topic.

Conclusions:

• Autophagy is a potential target for mitigating cisplatin ototoxicity.
• Further research into modulating autophagy could yield protective therapies.
• Interventions using autophagy activators or inhibitors warrant investigation.