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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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Related Experiment Video

Updated: Dec 27, 2025

Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm

Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm

Published on: January 28, 2011

Understanding DNA Methylation Patterns in Wheat.

Laura-Jayne Gardiner¹

¹Earlham Institute, Norwich, UK. Laura-Jayne.Gardiner@earlham.ac.uk.

Methods in Molecular Biology (Clifton, N.J.)

|February 24, 2020

Summary

This summary is machine-generated.

Analyzing wheat

Keywords:

DNA methylation Epigenomics Genomics Polyploid Wheat

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Last Updated: Dec 27, 2025

Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm

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Published on: January 28, 2011

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Published on: October 21, 2011

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

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Published on: September 7, 2017

Area of Science:

Genomics
Epigenetics
Bioinformatics

Background:

The bread wheat genome is large (17 Gb), allohexaploid, and highly repetitive (80-90%).
These characteristics present significant challenges and high costs for genomic and epigenomic analyses.
Understanding DNA methylation is crucial for wheat biology.

Purpose of the Study:

To provide an overview of recent bioinformatic and experimental methods.
To address the challenges of analyzing DNA methylation in the complex wheat genome.

Main Methods:

Bioinformatic approaches for analyzing large, repetitive genomes.
Experimental techniques for studying DNA methylation patterns.
Integration of computational and laboratory methods.

Main Results:

Overview of developed methods for wheat DNA methylation analysis.
Highlighting strategies to overcome genomic complexity.
Facilitating deeper understanding of epigenomic regulation in wheat.

Conclusions:

Recent advancements enable more effective DNA methylation studies in wheat.
These methods are essential for navigating the complexities of the wheat genome.
Improved understanding of wheat epigenomics is now more accessible.