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Updated: Dec 27, 2025
06:33
Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
8.0K
[Transthyretin amyloid cardiomyopathy]
Peter Riis Hansen1, Martin Krakauer
1prh@dadlnet.dk.
Ugeskrift for Laeger
|February 25, 2020
Summary
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a heart failure cause in the elderly. New imaging and treatments are improving ATTR-CM detection and management.
Area of Science:
- Cardiology
- Geriatrics
- Medical Imaging
Background:
- Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underrecognized cause of heart failure in older adults.
- ATTR-CM is linked to reduced life expectancy.
- Recent advancements offer new hope for diagnosis and treatment.
Purpose of the Study:
- To review recent developments in ATTR-CM detection and management.
- To highlight the growing recognition of ATTR-CM prevalence.
- To introduce the availability of effective treatments.
Main Methods:
- Diagnosis is now possible using radionuclide imaging with bone tracers.
- Confirmation requires the absence of plasma-cell dyscrasia.
- This review synthesizes current evidence on ATTR-CM.
Main Results:
- ATTR-CM is more prevalent than previously thought.
- Effective treatments for ATTR-CM are now available.
- New diagnostic tools have improved detection rates.
Conclusions:
- A new era in ATTR-CM detection and clinical management has begun.
- Early diagnosis and treatment can improve outcomes for patients with ATTR-CM.
- Increased awareness and improved diagnostic capabilities are crucial.
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