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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
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High-sensitivity C-reactive protein is associated with altered cardiac structure and function in psoriasis: The
Maria Dons1,2, Morten Sengeløv1,2, Kristoffer Grundtvig Skaarup1,2
1Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev & Gentofte, Denmark.
International Journal of Cardiology. Heart & Vasculature
|November 24, 2025
Summary
High sensitivity C-reactive protein (hsCRP) indicates inflammation and is linked to heart problems in psoriasis patients. Elevated hsCRP levels independently predict myocardial dysfunction, suggesting inflammation plays a role in cardiovascular risk.
Area of Science:
- Cardiology
- Dermatology
- Inflammation Research
Background:
- Psoriasis is linked to cardiovascular risk, with inflammation potentially playing a key role.
- High sensitivity C-reactive protein (hsCRP) is a biomarker for systemic inflammation.
Purpose of the Study:
- To assess the relationship between hsCRP levels and cardiac structure/function in individuals with psoriasis.
- To investigate if hsCRP is an independent predictor of myocardial dysfunction in psoriasis patients.
Main Methods:
- A cross-sectional cohort study involving 972 adults with psoriasis.
- hsCRP levels and transthoracic echocardiography were performed.
- Myocardial dysfunction defined by left ventricular ejection fraction (<50%) and/or global longitudinal strain (<16%).
Main Results:
- Higher hsCRP levels were associated with increased age, female sex, higher BMI, and greater cardiometabolic risk.
- The highest hsCRP tertile showed significantly higher rates of myocardial and diastolic dysfunction compared to the lowest tertile.
- Elevated hsCRP (>2 mg/L) was independently associated with a 45% increased odds of myocardial dysfunction.
Conclusions:
- Elevated hsCRP is independently associated with impaired systolic function (reduced GLS and LVEF) in psoriasis.
- Systemic inflammation, indicated by hsCRP, may contribute to early myocardial dysfunction in individuals with psoriasis.
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