Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

1.8K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.8K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

130
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
130
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

618
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
618
Aldehydes and Ketones with Alcohols: Hemiacetal Formation01:19

Aldehydes and Ketones with Alcohols: Hemiacetal Formation

9.1K
Similar to water, alcohols can add to the carbonyl carbon of the aldehydes and ketones. The addition of one molecule of alcohol to the carbonyl compound forms the hemiacetal or half acetal. As depicted below, in a hemiacetal, the carbon is directly linked to an OH and OR group.
9.1K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

242
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
242
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

194
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
194

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global Trends in National Alcohol Control Policies Between 2010-2019.

JHEP reports : innovation in hepatology·2026
Same author

Unbiased Spatial Proteomics Uncovers Hepatic in Situ Regulation in Alcohol-Associated Hepatitis.

The American journal of pathology·2026
Same author

Calpain-4 Knockdown Modulates Cholesterol Metabolism and LXRα Nuclear Localization in Experimental Alcohol-Related Liver Disease.

Alcohol, clinical & experimental research·2026
Same author

Implementation of evidence-based alcohol policies to reduce alcohol-related harm and liver disease to advance public health in Europe.

The Lancet regional health. Europe·2026
Same author

RECOMPENSATION FOLLOWING ALCOHOL-RELATED HEPATITIS IS ASSOCIATED WITH INCREASED SURVIVAL: RESULTS FROM A MULTICENTER STUDY.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Patient-specific modeling identifies metabolic interventions for reversing glucose use reprogramming in alcohol-associated hepatitis.

Communications biology·2026
Same journal

Exploring potential strategies to enhance memory and cognition in aging mice.

F1000Research·2026
Same journal

Construction an Implicit Block Multi-Steps Approach for Solving Sixth-Order Fractional Differential Equations.

F1000Research·2026
Same journal

Kansei Engineering in the Evolving Service Sector: A Decade of Insights.

F1000Research·2026
Same journal

A Safety-First Mindset:  Role of Patient Safety Culture in Enhancing Healthcare Workers' Emotional Intelligence.

F1000Research·2026
Same journal

Decoding Decisions: Personality-Interest Motivational Sequences as Predictors of Career Paths.

F1000Research·2026
Same journal

Beyond the Transparent Barrier: A Domain Visualization and Integrative Review of Contemporary Research on Gender-Based Professional Stasis.

F1000Research·2026
See all related articles

Related Experiment Video

Updated: Dec 27, 2025

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

15.0K

Recent advances in alcoholic hepatitis.

Vikrant Rachakonda1, Ramon Bataller1, Andres Duarte-Rojo1

  • 1Division of Gastroenterology and Hepatology, Starzl Transplantation Institute, and Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

F1000Research
|February 25, 2020
PubMed
Summary
This summary is machine-generated.

Alcoholic hepatitis, the most severe form of alcoholic liver disease, lacks effective treatments and recovery depends on abstinence. Rising alcohol use disorder necessitates better diagnosis, multidisciplinary care, and considering liver transplantation.

Keywords:
addictionbiomarkerscorticosteroidsliver transplantation

More Related Videos

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration
05:37

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Published on: May 31, 2018

12.6K
Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
10:42

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Published on: May 13, 2016

9.5K

Related Experiment Videos

Last Updated: Dec 27, 2025

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

15.0K
Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration
05:37

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Published on: May 31, 2018

12.6K
Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
10:42

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Published on: May 13, 2016

9.5K

Area of Science:

  • Hepatology
  • Gastroenterology
  • Addiction Medicine

Background:

  • Alcoholic hepatitis is the most severe manifestation of alcoholic liver disease.
  • It has a poor prognosis, with recovery primarily dependent on alcohol abstinence.
  • Increasing alcohol use disorder globally will escalate societal and healthcare burdens.

Purpose of the Study:

  • To review the current understanding and management of alcoholic hepatitis.
  • To highlight the importance of early diagnosis and multidisciplinary care.
  • To discuss the role of liver transplantation in managing severe alcoholic hepatitis.

Main Methods:

  • Literature review focusing on pathophysiology, diagnosis, and treatment of alcoholic hepatitis.
  • Analysis of prognostic factors and the role of liver biopsy.
  • Evaluation of current and emerging treatment strategies, including corticosteroids and transplantation.

Main Results:

  • Effective pharmacologic treatments are lacking, underscoring the need for abstinence.
  • Prognostic factors and liver biopsy aid in diagnosis, treatment decisions, and transplant referral.
  • A multidisciplinary approach is crucial for managing complications and comorbidities.

Conclusions:

  • Early identification and comprehensive management, including addressing complications and addiction, are vital.
  • Liver transplantation, with adequate post-transplant support, may offer a definitive solution for select patients.
  • Further research into pathophysiology may yield novel therapeutic options.