Related Experiment Video
Updated: Dec 27, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.6K
Shift Work and Prostate Cancer: An Updated Systematic Review and Meta-Analysis
Mario Rivera-Izquierdo1,2, Virginia Martínez-Ruiz1,3,4, Elena Mercedes Castillo-Ruiz1
1Department of Preventive Medicine and Public Health, School of Medicine, University of Granada, Avenida de la Investigación 11, Edificio A, 8ª planta, 18016 Granada, Spain.
International Journal of Environmental Research and Public Health
|February 26, 2020
Summary
Shift work, classified as a probable carcinogen, shows no confirmed link to prostate cancer in this meta-analysis. Further research with objective exposure data is needed to clarify any potential association.
Area of Science:
- Epidemiology
- Occupational Health
- Oncology
Background:
- Shift work is classified as a probable carcinogen by the International Agency of Research in Cancer (IARC).
- Existing epidemiological evidence on the association between shift work and prostate cancer is inconsistent and controversial.
- Understanding this relationship is crucial for public health and occupational safety.
Purpose of the Study:
- To investigate the potential association between shift work and prostate cancer incidence.
- To identify sources of heterogeneity in published studies.
- To analyze the impact of publication bias on the overall findings.
Main Methods:
- A systematic literature search was conducted for cohort and case-control studies published between January 1980 and November 2019.
- Study quality was assessed using the Newcastle-Ottawa Scale.
- Pooled odds ratios (OR) were calculated using random-effects models, with heterogeneity assessed by Cochran's Q test and stratified analyses.
Main Results:
- No significant association was found between rotating/night-shift work and prostate cancer (pooled OR 1.07; 95%CI 0.99 to 1.15).
- Heterogeneity was resolved when considering only cohort studies (pooled OR 1.03) or high-quality studies (pooled OR 0.99).
- Publication bias was detected, suggesting potential overestimation of effects in some studies.
Conclusions:
- The current data do not confirm an association between shift work and prostate cancer.
- High-quality studies and cohort studies specifically show no link.
- Future research requires more objective exposure variables to definitively assess the relationship.
