Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperpigmentation in megaloblastic anemia.

S H Lee1, W S Lee, K C Whang

  • 1Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.

International Journal of Dermatology
|October 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimized nerve block techniques while performing percutaneous hepatic ablation: <b>Literature review and practical use</b>.

Journal of interventional medicine·2021
Same author

Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus.

Lupus science & medicine·2016
Same author

A novel disposable, transnasal esophagoscope: a pilot trial of feasibility, safety, and tolerance.

Endoscopy·2012
Same author

The efficacy of portal vein embolization prior to right extended hemihepatectomy for hilar cholangiocellular carcinoma: a retrospective cohort study.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2011
Same author

Histologic diagnosis based on forceps biopsy is not adequate for determining endoscopic treatment of gastric adenomatous lesions.

Endoscopy·2010
Same author

Mangafodipir trisodium-enhanced MRI of hepatocellular carcinoma: correlation with histological characteristics.

Clinical radiology·2008
Same journal

Updated Vitiligo Trends in the Burden of Psychiatric and Autoimmune Diseases.

International journal of dermatology·2026
Same journal

SENTINOLD and the Challenge of Meaningful Risk Prediction in Melanoma.

International journal of dermatology·2026
Same journal

The "Stamp-n-Tack" Technique: An Ink-Guided Precision Method for Anchoring Tissue After Releasing Facial Retaining Ligaments in Large Facial Flap Reconstruction.

International journal of dermatology·2026
Same journal

Counterfactual Dermatology With Generative Models.

International journal of dermatology·2026
Same journal

Correlation of Clinical and Histopathological Features With Anti-Desmoglein Antibody Profile in Pemphigus Patients.

International journal of dermatology·2026
Same journal

Paracetamol-Induced Generalized Bullous Fixed Drug Eruption With Positive Anti-BP230 Antibody and Confirmed With Oral Provocation Test in a Child: A Case Report From the Philippines.

International journal of dermatology·2026
See all related articles

Vitamin B12 deficiency can cause skin hyperpigmentation and abnormal cell nuclei in patients with a history of gastric surgery. These symptoms resolved with vitamin B12 supplementation, highlighting its crucial role.

Area of Science:

  • Dermatology
  • Hematology
  • Gastroenterology

Background:

  • A 65-year-old woman with a history of gastric cancer surgery presented with hyperpigmentation.
  • The patient had undergone total gastrectomy and esophagojejunostomy 7 years prior.

Observation:

  • Hyperpigmentation of the hands and feet was observed.
  • Abnormally large nuclei were noted in keratinocytes within pigmented areas.
  • Megaloblastic anemia due to vitamin B12 deficiency was diagnosed.

Findings:

  • Skin pigmentation and nuclear abnormalities were reversible after vitamin B12 administration.
  • Ultrastructural analysis revealed intracytoplasmic desmosomes, tonofilament bundles, and condensed keratohyalin granules.
  • The study discusses the pathophysiological link between vitamin B12 deficiency, pigmentary changes, and nuclear morphology.

Related Experiment Videos

Implications:

  • This case highlights a potential cutaneous manifestation of vitamin B12 deficiency.
  • It underscores the importance of considering vitamin B12 assessment in patients with relevant surgical history and skin changes.
  • Early diagnosis and treatment of vitamin B12 deficiency can lead to complete resolution of associated dermatological findings.