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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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The immune...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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Finding lupus in the ANA haystack.

Nancy J Olsen1, David R Karp2

  • 1Division of Medicine, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.

Lupus Science & Medicine
|February 26, 2020
PubMed
Summary
This summary is machine-generated.

Diagnosing early systemic lupus erythematosus (SLE) is difficult. While the AVISE test shows promise for predicting SLE onset, its low sensitivity means many preclinical cases may be missed.

Keywords:
autoantibodiesautoimmunitysystemic lupus erythematosus

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Area of Science:

  • Rheumatology
  • Immunology
  • Diagnostic Medicine

Background:

  • Diagnosing systemic lupus erythematosus (SLE) early is challenging due to varied symptoms and unreliable screening tests like antinuclear antibody (ANA).
  • Low predictive value of double-stranded DNA autoantibodies further complicates early SLE diagnosis, leading to delayed specialist evaluation and potential disease progression.

Purpose of the Study:

  • To evaluate the utility of the AVISE Connective Tissue Disease Test in predicting the onset of SLE in patients with non-specific findings.
  • To assess if AVISE can provide prognostic information for early-stage SLE detection.

Main Methods:

  • Utilized the AVISE Connective Tissue Disease Test, a multiplex assay detecting autoantibodies and cell-bound complement products.
  • Tested clinic patients presenting with non-specific symptoms to determine AVISE's predictive capability for SLE onset.

Main Results:

  • The AVISE test offered more prognostic information for SLE compared to existing diagnostics.
  • However, the test demonstrated relatively low sensitivity, indicating a potential to miss a significant number of patients with preclinical SLE.

Conclusions:

  • While AVISE shows utility in distinguishing SLE and offers some prognostic value, its low sensitivity limits its effectiveness in screening for early or preclinical SLE.
  • There is a continued need for highly sensitive and specific diagnostic tests that can predict SLE risk and aid primary care providers in triaging patients.