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Time spent outside of target glucose range for young children with type 1 diabetes: a continuous glucose monitor

L A DiMeglio1, L G Kanapka2, D J DeSalvo3

  • 1Indiana University School of Medicine, Indianapolis, IN, USA.

Diabetic Medicine : a Journal of the British Diabetic Association
|February 26, 2020
PubMed

Insights

Young children with type 1 diabetes spent significant time in hyperglycemia and hypoglycemia. Minority race/ethnicity and higher parental education were linked to better glucose control, highlighting the need for targeted interventions.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Diabetes Research

Background:

  • Type 1 diabetes management in young children presents unique challenges.
  • Sensor glucose metrics are crucial for understanding glycemic control.
  • Continuous glucose monitoring (CGM) provides valuable insights into glucose fluctuations.

Purpose of the Study:

  • To investigate associations between demographic/clinical factors and sensor glucose metrics.
  • To analyze CGM data in children aged 2 to <8 years with type 1 diabetes.
  • To identify factors influencing time in target glucose range.

Main Methods:

  • Analysis of masked CGM data from 143 children (aged 2 to <8 years) in the USA.
  • Inclusion criteria: type 1 diabetes duration ≥3 months, HbA1c 53-86 mmol/mol.
  • Participants wore masked CGM devices for up to 14 days.

Main Results:

  • Children spent an average of 13 hours daily in hyperglycemia (>10.0 mmol/l) and ~1 hour in hypoglycemia (<3.9 mmol/l).
  • Minority race/ethnicity and higher parental education correlated with more time in target range (3.9-10.0 mmol/l) and less hyperglycemia.
  • Hypoglycemia was associated with minority race/ethnicity and younger age at diagnosis.

Conclusions:

  • Both hypoglycemia and hyperglycemia can negatively affect neurocognitive development in children.
  • Strategies are needed to improve time in target glucose range for young children with type 1 diabetes.
  • CGM data reveals disparities in glucose control among different demographic groups.
Abstract

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