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Tranylcypromine in social phobia.
M Versiani1, F D Mundim, A E Nardi
1Department of Psychiatry, Federal University of Rio de Janeiro, Brazil.
Journal of Clinical Psychopharmacology
|August 1, 1988
Summary
Tranylcypromine effectively treated social phobia in most patients, with 62% showing marked improvement. However, alcohol abuse correlated with poor outcomes, and side effects were common.
Area of Science:
- Psychiatry
- Clinical Psychology
Background:
- Social phobia is a debilitating anxiety disorder.
- Pharmacological interventions are a key treatment modality.
Purpose of the Study:
- To evaluate the efficacy and tolerability of tranylcypromine for social phobia.
- To identify factors associated with treatment outcome.
Main Methods:
- A 1-year open-label drug treatment study involving 32 patients with social phobia.
- Tranylcypromine was administered at dosages of 40-60 mg/day.
- Outcome was assessed based on clinical improvement and adverse events.
Main Results:
- 62% of patients (N=29) experienced marked improvement, and 17% showed moderate improvement.
- Alcohol abuse was linked to poorer treatment outcomes.
- Frequent side effects were observed, sometimes delaying optimal dosage attainment.
Conclusions:
- Tranylcypromine demonstrates significant efficacy in treating social phobia.
- Alcohol abuse is a negative prognostic factor.
- Further controlled studies are warranted to confirm these findings.