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Updated: Dec 27, 2025

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
Telomeres and Telomerase in Heart Ontogenesis, Aging and Regeneration
Denis Nalobin1, Svetlana Alipkina1, Anna Gaidamaka1
1Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russian.
Abstract:
The main purpose of the review article is to assess the contributions of telomere length and telomerase activity to the cardiac function at different stages of development and clarify their role in cardiac disorders. It has been shown that the telomerase complex and telomeres are of great importance in many periods of ontogenesis due to the regulation of the proliferative capacity of heart cells. The review article also discusses the problems of heart regeneration and the identification of possible causes of dysfunction of telomeres and telomerase.
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