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Related Experiment Video

Updated: Dec 27, 2025

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Published on: May 12, 2020

Treatment-Resistant Bacterial Keratitis: Challenges and Solutions.

Sait Egrilmez¹, Şeyda Yildirim-Theveny²

¹Private Office, Izmir, Turkey.

Clinical Ophthalmology (Auckland, N.Z.)

|February 27, 2020

Summary

Bacterial keratitis requires prompt treatment, addressing underlying causes and using appropriate antibiotics. Emerging options like corneal crosslinking offer hope against rising antibiotic resistance in eye infections.

Keywords:

antibiotic resistance bacterial keratitis corneal crosslinking multidrug resistant

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Last Updated: Dec 27, 2025

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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Area of Science:

Ophthalmology
Microbiology
Infectious Diseases

Background:

Bacterial keratitis is a leading cause of corneal blindness and an ophthalmic emergency.
Treatment resistance is often due to unaddressed predisposing factors, misdiagnosis, or mistreatment.
Increasing antibiotic resistance poses a significant challenge to managing bacterial keratitis.

Purpose of the Study:

To highlight the critical factors influencing treatment resistance in bacterial keratitis.
To emphasize the importance of diagnostic tools and empirical treatment strategies.
To discuss emerging treatment options and the growing threat of antimicrobial resistance.

Main Methods:

Review of diagnostic methods including smears, staining, and cultures for sight-threatening keratitis.
Analysis of common bacterial pathogens like *S. aureus*, CoNS, and *P. aeruginosa*.
Evaluation of current empirical and susceptibility-guided antibiotic treatment approaches.

Main Results:

High resistance rates (>30%) of *S. aureus* and CoNS to fluoroquinolone and methicillin are reported.
Multidrug resistance is prevalent in common gram-positive and gram-negative bacteria.
*P. aeruginosa* infections with multidrug-resistant isolates lead to poor visual prognosis.

Conclusions:

Eliminating predisposing factors and accurate diagnosis are crucial for effective bacterial keratitis management.
Antibiotic susceptibility testing, including agents like imipenem, colistin, and linezolid, is vital for resistant cases.
Corneal crosslinking presents a promising non-pharmaceutical approach for bacterial keratitis, especially with rising resistance.