Related Experiment Video
Updated: Dec 27, 2025
07:13
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
4.8K
Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents
Yun Jiang1, Karen E Wickersham2, Xingyu Zhang1
1University of Michigan School of Nursing, Ann Arbor, MI, USA.
Patient Preference and Adherence
|February 27, 2020
Summary
Patient adherence to oral anticancer agents (OAAs) is linked to managing side effects. Diarrhea severity significantly impacts adherence, highlighting the need for effective self-management strategies in OAA therapy.
Area of Science:
- Oncology
- Pharmacology
- Patient Self-Management
Background:
- Growing concerns exist regarding patient adherence to oral anticancer agents (OAAs).
- Effective self-management of OAA-related side effects is crucial for treatment success.
- Understanding the interplay between adherence, side effect severity, and self-management is vital.
Purpose of the Study:
- To assess the associations among adherence to capecitabine, the severity of side effects, and the effectiveness of self-management strategies.
- To investigate patient self-management of side effects in gastrointestinal cancer patients receiving capecitabine.
Main Methods:
- A pilot study involving 50 patients with gastrointestinal cancers receiving capecitabine.
- Adherence measured using the Medication Event Monitoring System over 6 weeks.
- Side effect severity and self-management effectiveness captured via the Modified Self-Care Diary.
Main Results:
- Overall mean adherence rate was 85.4%.
- Adherence was not significantly correlated with overall side effect severity but showed a weak correlation with self-management effectiveness at week 2.
- Severity of diarrhea at 6 weeks independently predicted adherence, influenced by age, medication count, health literacy, colorectal cancer diagnosis, and combination chemotherapy.
Conclusions:
- Severity of specific side effects, like diarrhea, and their self-management effectiveness are important factors in OAA adherence.
- Further research with larger sample sizes is needed to explore the complex relationships in OAA therapy.
- Ongoing examination of side effect management is merited for improving adherence to oral anticancer agents.
Related Concept Videos
01:16Kidney Transplant III: Nursing Management
263
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
263
01:23Hypertension V: Nursing Management
296
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
296
01:29Therapeutic Drug Monitoring: Affecting Factors
136
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
136
01:28Drug Therapy
202
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
202
01:27Nursing Ethical Principles II
2.0K
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
2.0K
01:24Dosage Regimen: Individualization
122
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
122