Related Experiment Video
Updated: Dec 27, 2025
09:34
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
Published on: February 9, 2019
9.3K
Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System
Shawqi H Alawdi1,2, Housam Eidi3, Marwa M Safar4,5
1Department of Pharmacology, Faculty of Medicine and Health Sciences, Thamar University, Dhamar, Yemen.
Nanotechnology, Science and Applications
|February 27, 2020
Summary
Researchers successfully loaded amlodipine onto nanodiamond particles. This breakthrough offers a potential nanodiamond drug delivery system for shuttling amlodipine across the blood-brain barrier for neurological disorder treatment.
Area of Science:
- Nanotechnology
- Materials Science
- Neuroscience
Background:
- Nanodiamonds are biocompatible drug carriers with proven brain penetration.
- The blood-brain barrier (BBB) impedes delivery of therapeutics like amlodipine.
- Amlodipine shows neuroprotective potential against conditions like Alzheimer's disease and stroke.
Purpose of the Study:
- To investigate the loading efficiency of amlodipine onto nanodiamond particles.
- To explore nanodiamonds as a potential drug delivery system for brain-targeted amlodipine.
Main Methods:
- Nanodiamonds were oxidized using a sulfuric and nitric acid mixture.
- Amlodipine adsorption was optimized in alkaline conditions (pH 8.5) with 2 mM NaOH.
- Loading was quantified using high-performance liquid chromatography and confirmed by FTIR spectroscopy and transmission electron microscopy.
Main Results:
- Optimal amlodipine loading reached 41% under specific alkaline conditions.
- FTIR spectroscopy confirmed the formation of nanodiamond-amlodipine conjugates.
- Transmission electron microscopy verified the successful loading of amlodipine onto nanodiamonds.
Conclusions:
- Demonstrated successful loading of amlodipine onto nanodiamond particles.
- Highlights the potential of nanodiamonds as a drug delivery platform for brain-targeted amlodipine.
- Suggests applicability for delivering other similar drugs across the BBB.
Related Concept Videos
01:27Bioavailability Enhancement: Drug Permeability Enhancement
142
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
142
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.5K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.5K
01:18Drug Delivery: Enteral Route
1.4K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.4K
01:16Drug Delivery: Overview
660
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
660
01:24Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
171
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
171
01:25Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
142
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
142