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Related Experiment Video

Updated: Dec 27, 2025

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

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Published on: February 10, 2015

Cholangiolytic Changes in Statin-Induced Liver Injury.

Preethi Dileep Menon¹, Tamneet Singh², Hopethe Hubbard²

¹Department of Pathology and Laboratory Medicine, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, USA.

Case Reports in Pathology

|February 27, 2020

Summary

Atorvastatin, a common cholesterol drug, can cause liver injury. This case highlights unusual liver biopsy findings and emphasizes that stopping atorvastatin normalized liver function tests.

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Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

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Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

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Published on: February 10, 2015

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

Area of Science:

Hepatology
Pharmacology
Gastroenterology

Background:

Atorvastatin is a widely prescribed statin for lowering cholesterol.
Statin therapy, including atorvastatin, is associated with potential side effects like myalgia and headache.
Drug-induced liver injury (DILI) is a known risk, with atorvastatin frequently implicated.

Observation:

A 58-year-old woman on atorvastatin presented with recurrent abdominal pain and biliary tree dilation.
Initial symptoms were attributed to post-surgical complications, despite elevated liver function tests.
Liver biopsy revealed portal and lobular inflammation with cholangiolysis, indicating a mixed pattern of liver injury.

Findings:

The patient displayed a mixed pattern of liver injury, characterized by elevated liver function tests.
Histologic examination showed portal and lobular inflammation with cholangiolysis.
Cessation of atorvastatin therapy led to the normalization of liver function tests.

Implications:

This case underscores the importance of considering statin-induced hepatotoxicity in patients with unexplained liver function abnormalities.
Unusual histologic findings, such as cholangiolysis, can be associated with atorvastatin-induced liver injury.
Discontinuation of the offending statin agent is crucial for resolving drug-induced liver injury.