Related Experiment Video
Updated: Dec 27, 2025
04:44
Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice
Published on: February 16, 2024
2.0K
Prolonged Hypercalcemia-Induced Psychosis.
Lauren Nagy1, Pratheek Mangini1, Caitlin Schroen1
1Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Case Reports in Psychiatry
|February 27, 2020
Summary
Hypercalcemia can cause psychosis, but this case shows persistent symptoms even after parathyroid adenoma removal. This highlights potential long-term neurological effects of prolonged high calcium levels.
Area of Science:
- Neuroendocrinology
- Psychiatry
- Calcium Metabolism
Background:
- Hypercalcemia, often caused by parathyroid adenoma, is linked to neuropsychiatric dysfunction.
- High calcium levels may induce neuronal damage via excitotoxicity and neurotransmitter imbalance.
Observation:
- A patient with no prior psychiatric history developed prolonged delirium and psychosis post-parathyroid adenoma removal.
- Symptoms persisted for at least 8 months despite medical clearance and were unresponsive to psychotropic medications.
Findings:
- This case presents a rare instance of persistent psychosis following correction of hypercalcemia.
- Prolonged hypercalcemia exposure may lead to enduring neuropsychiatric sequelae.
Implications:
- Further research is needed to understand mechanisms of persistent psychosis after hypercalcemia.
- Consideration of prolonged neuropsychiatric monitoring in patients with severe or prolonged hypercalcemia is warranted.
More Related Videos
Related Concept Videos
01:26Psychosis: Goals of Pharmacotherapy
395
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
395
01:28Psychosis and Antipsychotic Drugs: Overview
729
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
729
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.7K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.7K
01:24Mania and Antimanic Drugs: Overview
493
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
493
01:20Desensitization and Tachyphylaxis
2.9K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.9K
01:05Long-term Depression
32.9K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
32.9K