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Related Experiment Video

Updated: Dec 27, 2025

Author Spotlight: Advancing Syphilis Research &#8212; Innovations in Treponema pallidum Cultivation and Genetic Engineering
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Ocular syphilis in an immunocompetent host.

Moni Roy1,2, Ashish K Roy1, John J Farrell2,3

  • 1OSF Saint Francis Medical Center, Peoria, IL, USA.

Idcases
|February 27, 2020
PubMed
Summary
This summary is machine-generated.

Ocular syphilis, a known complication, is underdiagnosed despite rising syphilis rates. Early recognition and sexual history are crucial for preventing vision loss, even in HIV-negative patients.

Keywords:
ImmunocompetentOcular syphilisSyphilis

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Public Health

Background:

  • Syphilis rates have been increasing in the U.S. since 2000.
  • Ocular syphilis is a known complication but often underdiagnosed.
  • Recent cases are predominantly in men who have sex with men (MSM), but 50% are HIV-negative.

Observation:

  • A case of acute iridocyclitis and ocular hypertension caused by syphilis infection is presented.
  • This highlights the diagnostic challenge of ocular syphilis.
  • The patient was immunocompetent and HIV-negative.

Findings:

  • Ocular syphilis can present with varied symptoms, including iridocyclitis and elevated intraocular pressure.
  • Timely diagnosis is essential to prevent irreversible visual impairment.
  • Syphilis should be considered in the differential diagnosis of uveitis and other ocular inflammatory conditions.

Implications:

  • Increased awareness among healthcare providers is needed for prompt diagnosis of ocular syphilis.
  • Ocular syphilis should be considered in immunocompetent, HIV-negative individuals presenting with relevant symptoms.
  • Taking a detailed sexual history is vital for diagnosing syphilis and its ocular manifestations.