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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
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Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology.

Shantanu Pradhan1,2, Omar A Banda1, Cindy J Farino1

  • 1Department of Biomedical Engineering, University of Delaware, 150 Academy Street, 161 Colburn Lab, Newark, DE, 19716, USA.

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|February 27, 2020
PubMed
Summary

Understanding vascular mechanics is key to treating diseases. New microphysiological systems help study how blood flow forces impact organ health and disease, paving the way for novel therapies.

Keywords:
endothelial cellshydrogelsmechanotransductionmicrofluidic devicesmicrophysiological systemsorgan-on-a-chipshear stresstissue engineering

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Area of Science:

  • Biomedical Engineering
  • Vascular Biology
  • Mechanobiology

Background:

  • The vascular system is crucial for organ function and homeostasis.
  • Vascular dysfunction contributes to numerous diseases.
  • Tissue-engineered and microphysiological systems accelerate research into vascular roles.

Purpose of the Study:

  • To review vascular structure, function, and the role of hemodynamic forces.
  • To explore measurement techniques for vascular mechanical properties.
  • To summarize in vitro microvascular system fabrication and applications in mechanobiology.

Main Methods:

  • Review of existing literature on vascular biology and mechanobiology.
  • Description of state-of-the-art in vitro microvascular system fabrication.
  • Discussion of measurement approaches for mechanical properties at cellular and tissue levels.

Main Results:

  • Hemodynamic forces are vital for vascular homeostasis.
  • In vitro systems allow detailed study of vascular networks and parenchymal interactions.
  • Mechanotransduction pathways are critical for vascular health and disease.

Conclusions:

  • Understanding vascular mechanobiology is essential for developing new treatments.
  • In vitro microphysiological systems are powerful tools for studying vascular-parenchymal mechanotransduction.
  • Further research into vascular mechanobiology may lead to novel mechanotherapeutics.