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Dengue: Status of current and under-development vaccines
Marianna Redoni1, Sophie Yacoub2,3, Laura Rivino4
1Infectious Diseases Department, University Hospital of Trieste, Trieste, Italy.
Reviews in Medical Virology
|February 27, 2020
Summary
Developing effective dengue vaccines is crucial due to increasing outbreaks. Current research focuses on novel immunization strategies and advanced vaccine candidates to improve safety and efficacy beyond existing options.
Area of Science:
- Virology
- Immunology
- Public Health
Background:
- Dengue is a growing mosquito-borne viral disease with a wide range of clinical presentations.
- No specific antiviral treatments exist, with care limited to supportive measures.
- Existing dengue vaccines have limitations, necessitating the development of safer and more effective alternatives.
Purpose of the Study:
- To review the current research status of dengue vaccine development.
- To highlight novel immunization strategies and advanced vaccine candidates.
Main Methods:
- Literature review of current dengue vaccine research.
- Analysis of clinical and pre-clinical trial data for vaccine candidates.
- Overview of novel immunization strategies in dengue vaccine development.
Main Results:
- Dengvaxia is the first licensed dengue vaccine but has strict usage limitations.
- Several vaccine candidates are in clinical and pre-clinical trials.
- Advanced candidates include live-attenuated vaccines like TDV and TDV 003/005, with 15 other vaccines in development.
Conclusions:
- There is a significant need for improved dengue vaccines.
- Ongoing research is exploring diverse and innovative approaches to dengue immunization.
- The development pipeline shows promise for future dengue prevention strategies.
