[Research Progress in Consistency of Driver Gene Status between Primary and Corresponding Metastatic Lesions in...

Non-small cell lung cancer (NSCLC), as the most common pathological type of lung cancer, has the characteristics of high malignancy and aggressiveness, and the lymph nodes and different organ metastases are prone to occur in advanced stages. In recent years, with the development of precision medicine, drug resistance and treatment failure in NSCLC metastasis sites have brought difficulties for molecular targeted therapy. And studies have confirmed that these may be related to new molecular changes after tumor metastasis. This review is to describe the state of the driving genes in the primary and metastatic sites of NSCLC, and systematically review the research progress on the consistency of the state of the driving genes between the primary and corresponding metastatic lesions, which provides a new idea for exploring the molecular targeted therapy of metastatic NSCLC.