Related Experiment Video

Updated: Dec 27, 2025

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

681

Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy

Clodagh P O'Neill1, Róisín M Dwyer1,2

  • 1Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Galway, H91 YR71, Ireland.

Cells
|February 28, 2020
PubMed

Insights

Novel nanoparticles effectively deliver tumor suppressor microRNAs to cancer sites, overcoming delivery challenges for improved cancer therapy. This approach shields microRNAs, enhancing their expression and targeting efficacy in vivo.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • MicroRNAs (miRNAs) function as tumor suppressors by inhibiting oncogenic pathways.
  • Effective delivery of miRNAs to tumors remains a significant challenge in cancer therapy.

Purpose of the Study:

  • To review nanoparticle-based delivery systems for tumor suppressor microRNAs.
  • To highlight strategies overcoming miRNA degradation, transient expression, and poor targeting.

Main Methods:

  • Review of studies on natural and synthetic nanoparticle delivery vehicles.
  • Analysis of engineered nanoparticles for targeted delivery of tumor suppressor miRNAs.

Main Results:

  • Nanoparticles show promise in shielding miRNAs from degradation.
  • Engineered nanoparticles facilitate targeted delivery of miRNAs to tumor sites.
  • Both natural and synthetic nanoparticles are being explored for miRNA delivery.

Conclusions:

  • Nanoparticle-mediated delivery is a viable strategy for enhancing tumor suppressor miRNA therapy.
  • Further development of nanoparticle vehicles is crucial for effective in vivo miRNA delivery.
  • Targeted delivery of miRNAs via nanoparticles offers a promising therapeutic avenue for cancer treatment.
Keywords:
cancer therapynanoparticle deliverytumor suppressor miRNA

More Related Videos

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

3.0K
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

260

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.8K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
7.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.5K