Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.6K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.6K
Epigenetic Regulation01:46

Epigenetic Regulation

33.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.3K
Negative Regulator Molecules01:23

Negative Regulator Molecules

38.1K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.1K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.2K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.2K
Abnormal Proliferation02:23

Abnormal Proliferation

5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

2.6K
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis.

Nature aging·2025
Same author

Identification of a Novel Glycosyltransferase Prognostic Signature in Hepatocellular Carcinoma Based on LASSO Algorithm.

Frontiers in genetics·2022
Same author

Multistimuli-Responsive Squaraine Dyad Exhibiting Concentration-Controlled Vapochromic Luminescence.

ACS applied materials & interfaces·2022
Same author

Fabrication of 3D GelMA Scaffolds Using Agarose Microgel Embedded Printing.

Micromachines·2022
Same author

Reclassification of <i>Enterobacter</i> sp. FY-07 as <i>Kosakonia oryzendophytica</i> FY-07 and Its Potential to Promote Plant Growth.

Microorganisms·2022
Same author

Three-Dimensional Microfilament Printing of a Decellularized Extracellular Matrix (dECM) Bioink Using a Microgel Printing Bath for Nerve Graft Fabrication and the Effectiveness of dECM Graft Combined with a Polycaprolactone Conduit.

ACS applied bio materials·2022

Related Experiment Video

Updated: Dec 27, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

3.2K

Two conserved epigenetic regulators prevent healthy ageing.

Jie Yuan1,2, Si-Yuan Chang1,2, Shi-Gang Yin3,2,4

  • 1Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.

Nature
|February 28, 2020
PubMed
Summary

Scientists discovered an epigenetic mechanism that negatively regulates healthy aging. This involves specific genes that, when altered, can prevent age-related decline and improve healthspan in model organisms.

More Related Videos

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.7K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.5K

Related Experiment Videos

Last Updated: Dec 27, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

3.2K
Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.7K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.5K

Area of Science:

  • Epigenetics and Aging
  • Neuroscience
  • Genetics

Background:

  • Global life expectancy has increased, but healthspan has not proportionally improved.
  • Understanding the biological basis of healthy aging is crucial.
  • Lifespan and healthspan can be dissociated, highlighting the need to study healthy aging mechanisms.

Purpose of the Study:

  • To identify conserved epigenetic mechanisms regulating healthy aging.
  • To investigate genes that modulate age-related behavioral deterioration.
  • To explore potential therapeutic targets for promoting healthy aging.

Main Methods:

  • Genome-wide RNA interference (RNAi) screen in *Caenorhabditis elegans* to identify genes affecting age-related behavioral decline.
  • Investigated the role of specific epigenetic regulators (BAZ-2 and SET-6) in *C. elegans*.
  • Validated findings in cultured mouse neurons and human cells, and examined human databases and mouse models.

Main Results:

  • Identified 59 genes modulating age-related behavioral deterioration in *C. elegans*.
  • Discovered that neuronal epigenetic regulators BAZ-2 and SET-6 accelerate aging by impairing mitochondrial function.
  • Showed that the human orthologs (BAZ2B, EHMT1) increase with age and correlate with Alzheimer's disease progression; *Baz2b* ablation in mice prevents cognitive decline and unhealthy weight gain.

Conclusions:

  • A conserved epigenetic mechanism involving BAZ-2 and SET-6 negatively regulates healthy aging.
  • These epigenetic regulators impact mitochondrial function and are linked to age-related cognitive decline.
  • The findings suggest potential targets for interventions to promote healthy aging and extend healthspan.