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Updated: Dec 27, 2025

Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice
Published on: April 15, 2014
Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies
Elia Sechi1, Karl N Krecke2, Sean J Pittock3
1Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Background:
Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty.
Objective And Methods:
We retrospectively investigated the frequency of negative spinal cord MRI (performed <6 weeks from onset) in Mayo Clinic patients with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated myelitis (2000-2019).
Results:
The initial spinal cord MRI was negative in 7/73 (10%) patients, despite severe acute disability (median EDSS, 7 (range, 4.5-8)); myelitis symptoms/signs were frequent (paraparesis, neurogenic bladder, sensory level, Lhermitte's phenomenon). Myelitis lesions became overt at follow-up MRI in three patients.
Conclusions:
A negative spinal cord MRI should not dissuade from MOG-IgG testing in patients with acute/subacute myelitis.
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