Synthesis, Characterization and DNA Binding Investigations of a New Binuclear Ag(I) Complex and Evaluation of Its Anticancer Property
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Updated: Dec 27, 2025
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Mian-Hong Zheng1, Fahime Bigdeli2, Lan-Xing Gao1
1College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, People's Republic of China.
Aim:
A new Ag(I) complex (A3) was synthesized and evaluated for its anticancer activity against human cancer cell lines.
Materials And Methods:
The complex A3 was characterized by 1H, 13C, and 31P nuclear magnetic resonance (NMR), infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complex with CT-DNA was studied by electronic absorption spectra, fluorescence spectroscopy, and cyclic voltammetry; cell viability (%) was assessed by absorbance measurement of the samples.
Results:
The interaction mode of the complex A3 with DNA is electrostatic, and this complex shows good potential in anticancer properties against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with 0.5 micromolar concentrations.
Conclusion:
The Ag(I) complex could interact with DNA noncovalently and has anticancer properties.
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