Prognostic Values of LDH and CRP in Cervical Cancer
Han Wang1, Meng-Sen Wang2, Yong-Heng Zhou1
1Department of Oncology, Jining Cancer Hospital, Jining, Shandong, People's Republic of China.
Purpose:
Cervical cancer is one of the deadliest tumors among women in China. C-reactive protein (CRP), an indicator of inflammation, and lactate dehydrogenase (LDH), an enzyme ubiquitously expressed in cells, both play important roles in tumor growth and metastasis.
Patients And Methods:
Based on pre-radiotherapy LDH and CRP median levels, we divided patients into four groups: high LDH and CRP group, high LDH group, high CRP group, and low LDH and CRP group. Then, based on pre-/post-radiotherapy LDH and CRP ratios, we divided patients into four groups: high LDH and CRP ratio group, high LDH ratio group, high CRP ratio group, and low LDH and CRP ratio group. Kaplan-Meier (KM) curves were constructed to show overall survival (OS). A multivariate Cox regression model was employed to identify the independent risk factors.
Results:
High pre-radiotherapy LDH and CRP levels and increased pre-/post-radiotherapy LDH and CRP ratios were correlated with worst OS compared with the other three groups.
Conclusion:
LDH and CRP were correlated with outcomes in patients with locally advanced cervical cancer.
