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Liquisolid technique and its applications in pharmaceutics
Mei Lu1, Haonan Xing1, Jingzheng Jiang1
1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Asian Journal of Pharmaceutical Sciences
|February 28, 2020
Summary
The liquisolid technique enhances the dissolution and bioavailability of poorly water-soluble drugs. This advanced pharmaceutical approach offers cost-effective, simple processing for improved drug delivery and sustained release.
Area of Science:
- Pharmaceutics
- Drug Delivery Systems
Background:
- Many new drug candidates exhibit poor water solubility, posing challenges for pharmaceutical formulation.
- Enhancing drug dissolution and bioavailability is crucial for effective therapeutic outcomes.
Purpose of the Study:
- To provide an overview of the liquisolid technique.
- To summarize advancements in its pharmaceutical applications.
Main Methods:
- The liquisolid technique converts liquid drug formulations into dry, free-flowing powders.
- This method involves specific excipient selection and processing.
Main Results:
- The liquisolid technique significantly enhances the dissolution rate of poorly water-soluble drugs.
- It also demonstrates potential for sustained drug release and improved photostability.
Conclusions:
- The liquisolid technique is a promising, cost-effective approach for improving drug solubility and delivery.
- Its applications in pharmaceutics are expanding, offering solutions for challenging drug candidates.
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