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Near-infrared ratiometric self-assembled theranostic nanoprobe: imaging and tracking cancer chemotherapy
Xinwei Tian1, Zhao Li1, Ning Ding1
1Shaanxi Engineering Laboratory for Food Green Processing and safety Control, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China. lizhao0309@snnu.edu.cn.
Abstract:
We have developed a novel near-infrared ratiometric fluorescent theranostic nanoprobe. Upon reaction with glutathione, it releases a near-infrared fluorophore and chemotherapy drug. Notably, this nanoprobe can selectively kill HeLa and HepG-2 cancer cells over normal HUVEC cells with negligible side effects. Furthermore, this nanoprobe has been successfully applied to real-time fluorescence tracking and imaging cancer therapy in mice.
