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[Mast cell activation syndrome. About a clinical case]
Ricardo Cardona1, Maria Angélica Muñoz-Ávila, Catalina Gómez-Henao
1Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín, Colombia. rcv2016udea@gmail.com.
Background:
Monoclonal mast cell activation syndrome is included in mast cell activation disorders in which, after a diagnostic process, it is not possible to meet the required criteria for a diagnosis of systemic mastocytosis.
Clinical Case:
A 73-year-old woman who presented two events of anaphylaxis 15 minutes after the intake of yucca; with a positive skin test, elevated tryptase, and mast cells with abnormal phenotype in the bone marrow biopsy, and without criteria for systemic mastocytosis.
Conclusion:
The diagnosis of monoclonal mast cell activation syndrome requires high clinical suspicion for patients with recurrent anaphylaxis and elevated tryptase, for whom joint management with hematology is essential.
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