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New curtachalasin from the Xylaria sp. DO 1801
Jia Wang1, Yining Sang1, Siqi Tang1
1School of Pharmacy of Tongji Medical College, Huazhong University of Science and Technology, WuHan, China.
Natural Product Research
|February 29, 2020
Abstract:
One new cytochalasin, named curtachalasin Q (1), together with 8 known cytochalasins were isolated from the ethyl acetate extract of the Xylaria sp. DO1801. The structure of the new compound was elucidated on the basis of IR, UV, HR-ESI-MS, NMR spectra and X-ray diffraction. Compound 1 and 2 were not cytotoxic (IC50>50uM) against four tumour cell lines (SW-1990, ASPC-1, HepG2 and Hep3B).

