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Proton Beam Therapy in Liver Malignancies.
Osman Siddiqui1, Ariel Pollock1, Santanu Samanta1
1Department of Radiation Oncology, University of Maryland Medical Center, 22 South Greene Street, Baltimore, MD, 21201, USA.
Current Oncology Reports
|February 29, 2020
Summary
Proton beam therapy (PBT) offers superior normal tissue sparing for liver malignancies compared to X-ray therapy. This advanced radiation technique provides excellent local control and treatment tolerance, with growing accessibility.
Area of Science:
- Radiation Oncology
- Medical Physics
Background:
- Proton beam therapy (PBT) enhances normal tissue sparing over conventional X-ray therapy.
- This is critical for liver malignancies due to proximity to organs at risk and risk of radiation-induced liver disease (RILD).
Purpose of the Study:
- To review the efficacy and safety of PBT for liver malignancies.
- To highlight the advantages of PBT in minimizing radiation-induced liver disease (RILD) and protecting gastrointestinal (GI) organs.
Main Methods:
- Review of multi-center data on PBT for liver tumors.
- Analysis of treatment outcomes, including local control and toxicity.
Main Results:
- Multi-center data confirm PBT safely delivers high ablative radiation doses.
- Excellent local control and good treatment tolerance are achieved with PBT.
- PBT demonstrates long-standing evidence of efficacy and increasing availability.
Conclusions:
- PBT is an effective and safe treatment modality for liver malignancies.
- PBT offers significant advantages in sparing organs at risk and reducing RILD.
- The increasing availability of PBT expands treatment options for liver cancer patients.
