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An Unusual Recurrence of Miller Fisher Syndrome: Three Times in Eight Years
Zeynep Özözen Ayas1, Yeşim Güzey Aras1, Belma Doğan Güngen2
1Sakarya University Training and Research Hospital, Department of Neurology, Sakarya, Turkey.
Abstract:
Miller Fisher Syndrome (MFS) is an acute, autoimmune polyneuropathy usually associated with a good prognosis which is clinically characterized by ataxia, ophtalmoplegia, and areflexia. MFS has a monophasic course, double recurrence can be seen in rare cases. But three attacks are very rare. In this article, we discussed a rare case of MFS and approach to the treatment that recurred 3 times within a period of 8 years. It is emphasized that MFS cases may occur a recurring pattern, and plasma exchange should be definitely tried as a therapeutic approach when clinical deterioration occurs under intravenous immunoglobulin (IVIg) therapy.
Insights
Miller Fisher Syndrome (MFS) is a rare autoimmune disorder. This case highlights MFS recurrence three times, suggesting plasma exchange as a treatment option when IVIg is ineffective.
Area of Science:
- Neurology
- Autoimmune Diseases
Background:
- Miller Fisher Syndrome (MFS) is an acute autoimmune polyneuropathy.
- It typically presents with ataxia, ophthalmoplegia, and areflexia, usually with a good prognosis.
Observation:
- MFS commonly follows a monophasic course, with rare instances of double recurrence.
Findings:
- This article details an exceptionally rare case of MFS recurring three times over eight years.
Implications:
- MFS can exhibit a recurring pattern, challenging typical prognoses.
- Plasma exchange is a crucial therapeutic consideration for MFS cases with clinical deterioration despite intravenous immunoglobulin (IVIg) treatment.
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