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Blood Viscoelasticity Measurement Using Interface Variations in Coflowing Streams under Pulsatile Blood Flows
1Department of Mechanical Engineering, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Korea.
Micromachines
|March 1, 2020
Summary
This study introduces a microfluidic method to measure blood viscoelasticity under pulsatile flow conditions. The technique quantifies interface variations to determine blood viscosity and compliance, aiding disease monitoring.
Area of Science:
- Biomedical Engineering
- Microfluidics
- Rheology
Background:
- Blood flow in microcirculation is dictated by blood's mechanical properties, crucial for disease screening.
- Measuring blood viscoelasticity under pulsatile conditions is essential for accurate disease status assessment.
Purpose of the Study:
- To develop and demonstrate a novel microfluidic method for measuring blood viscoelasticity.
- To quantify blood viscosity and compliance using interface variations in coflowing streams under pulsatile flow.
Main Methods:
- A T-shaped microfluidic device was designed with separate channels for blood sample and reference fluid.
- Blood was infused at a sinusoidal flow rate using syringe pumps, while reference fluid flowed constantly.
- Viscoelasticity (viscosity and compliance) was analytically derived from interface variations using a fluidic circuit model.
Main Results:
- Compliance was significantly influenced by the flow period.
- Hematocrit and diluents affected blood viscosity and compliance.
- Viscoelasticity of glutaraldehyde-fixed red blood cells varied with concentration.
Conclusions:
- The developed microfluidic method effectively monitors blood viscoelasticity under pulsatile flow.
- This technique offers a promising approach for disease monitoring through blood mechanical property assessment.
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