Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Flow

Blood Flow

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Microfluidic Method for Simultaneous Assessment of Blood Viscosity and Red Blood Cell Aggregation During Continuous Syringe Delivery.

Sensors (Basel, Switzerland)·2026

Same author

Full Hematocrit-Viscosity Curve Identification Using Three-Dataset Krieger-Dougherty Regression.

Biosensors·2026

Same author

Biomechanical Investigation of Red Cell Sedimentation Using Blood Shear Stress and Blood Flow Image in a Capillary Chip.

Micromachines·2023

Same author

Quantification of Blood Viscoelasticity under Microcapillary Blood Flow.

Micromachines·2023

Same author

Biomechanical Assessment of Red Blood Cells in Pulsatile Blood Flows.

Micromachines·2023

Same author

Biosensing of Haemorheological Properties Using Microblood Flow Manipulation and Quantification.

Sensors (Basel, Switzerland)·2023

Same journal

Correction: Kang et al. Fluid Flow to Electricity: Capturing Flow-Induced Vibrations with Micro-Electromechanical-System-Based Piezoelectric Energy Harvester. <i>Micromachines</i> 2024, <i>15</i>, 581.

Micromachines·2026

Same journal

Femtosecond Laser Texturing of Wood Coatings with Bio-Based Epoxy and Wax Additives for Enhanced Hydrophobicity.

Micromachines·2026

Same journal

Engineering of Optoelectronic Devices for Renewable Energy Applications.

Micromachines·2026

Same journal

Phase Transformation and Electrochemical Behavior of Hexagonal TiO<sub>2</sub> Nanotubes Under Different Annealing Temperatures and Heating Rates.

Micromachines·2026

Same journal

Process Optimization and Predictive Modeling of Femtosecond Laser Precision Milling for Commercial PMMA Slices.

Micromachines·2026

Same journal

A Hybrid Preprocessing Multi-Objective Surrogate Model for Thermal MEMS Actuators.

Micromachines·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows

Published on: April 25, 2013

Micro Blood Flow-Resolved Rheometry.

Yang Jun Kang¹

¹Department of Mechanical Engineering, Chosun University, 10, Chosundae 1-gil, Dong-gu, Gwangju 61452, Republic of Korea.

|March 28, 2026

Summary

This summary is machine-generated.

A new microfluidic method accurately measures red blood cell (RBC) aggregation and blood viscosity. This approach overcomes previous limitations, enabling precise analysis of blood properties and cellular changes.

Keywords:

blood flow-dependent RBC aggregation blood image rate blood velocity fields blood viscosity microfluidic chip two-step blood delivery

More Related Videos

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation

Published on: June 4, 2015

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

Published on: April 19, 2018

Related Experiment Videos

Last Updated: Mar 29, 2026

Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows

Published on: April 25, 2013

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation

Published on: June 4, 2015

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

Published on: April 19, 2018

Area of Science:

Biomedical Engineering
Microfluidics
Hematology

Background:

Assessing blood properties like red blood cell (RBC) aggregation and viscosity is crucial.
Existing microfluidic methods face challenges including dead-volume loss, RBC sedimentation, and flow rate control.

Purpose of the Study:

To develop a novel microfluidic method for accurate RBC aggregation and blood viscosity measurement.
To address limitations of previous techniques in microfluidic blood analysis.

Main Methods:

A microfluidic chip with distinct channels for high (main) and low (aggregation) shear rates.
A two-step blood delivery system using an air cavity for RBC aggregation and a syringe pump for viscosity measurements.
Analysis of time-lapse image intensity and flow rate to determine RBC aggregation index and blood viscosity.

Main Results:

Validated fluid viscosity measurements using glycerin solutions.
Demonstrated the method's ability to detect differences in hematocrit and dextran concentrations.
Successfully identified changes in heat-shocked RBCs, indicating sensitivity to cellular alterations.

Conclusions:

The proposed microfluidic method offers accurate and reliable measurement of RBC aggregation and blood viscosity.
This technique effectively overcomes common challenges in microfluidic blood analysis.
The method is capable of detecting significant changes in RBCs and blood medium properties.