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Related Concept Videos

CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

579
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
579
Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

521
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
521

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Updated: Dec 27, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
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Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity.

Katrin H Preller1, Patricia Duerler2, Joshua B Burt3

  • 1Neuropsychopharmacology and Brain Imaging Unit, University Hospital for Psychiatry Zurich, Zurich, Switzerland; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

Biological Psychiatry
|March 1, 2020
PubMed
Summary
This summary is machine-generated.

Psilocybin alters brain connectivity, decreasing associative and increasing sensory networks over time. Baseline connectivity predicts the magnitude of these psychedelic-induced changes, highlighting serotonin receptor roles.

Keywords:
Functional connectivityGlobal brain connectivityPsilocybinReceptor gene expressionSerotoninfMRI

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Brain Imaging

Background:

  • Renewed interest in psychedelics like psilocybin has spurred research into their mechanisms of action.
  • The time-dependent, systems-level neurobiology of psychedelics in humans is not well understood.

Purpose of the Study:

  • To investigate the time-dependent neurobiological effects of psilocybin on brain connectivity in humans.
  • To explore the relationship between psilocybin-induced brain changes, baseline connectivity, and gene expression patterns of serotonin receptors.

Main Methods:

  • A double-blind, randomized, crossover study involving 23 healthy participants receiving placebo or psilocybin (0.2 mg/kg).
  • Resting-state functional connectivity was measured using magnetic resonance imaging at 20, 40, and 70 minutes post-administration.
  • Connectivity data was analyzed using a global brain connectivity method and compared with cortical gene expression.

Main Results:

  • Psilocybin reduced associative brain connectivity while increasing sensory connectivity over time.
  • Baseline functional connectivity was associated with the magnitude of psilocybin-induced changes.
  • Psilocybin-induced changes correlated with the spatial gene expression of 5-HT2A and 5-HT1A receptors.

Conclusions:

  • The psychedelic state may involve altered integration of sensory and disintegration of associative brain networks.
  • Serotonin 2A and 1A receptor systems play a critical role in psilocybin's effects.
  • Baseline connectivity may predict individual responses to psilocybin, informing personalized psychedelic medicine approaches.