Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A variant in RESF1 is associated with Addison's disease and multiple autoimmune syndrome in young Nova Scotia Duck Tolling Retrievers.

Scientific reports·2026

Same author

Morphologic Deciphering of Hematopoietic Cell Vacuolization: Lessons From VEXAS Syndrome and Other Etiologies.

International journal of laboratory hematology·2026

Same author

Erratum: Phase II Study of Acalabrutinib, Venetoclax, and Obinutuzumab in a Treatment-Naïve Chronic Lymphocytic Leukemia Population Enriched for High-Risk Disease.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2025

Same author

Trans-differentiation of plasma cell neoplasm to acute myeloid leukemia with monocytic features: Case report of divergent phenotype with identical genotype.

Leukemia research reports·2025

Same author

Phase II Study of Acalabrutinib, Venetoclax, and Obinutuzumab in a Treatment-Naïve Chronic Lymphocytic Leukemia Population Enriched for High-Risk Disease.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2024

Same author

Ulcerative Jejunitis in Celiac Disease: A 30-Year US Experience.

The American journal of gastroenterology·2024

Same journal

Invasive urothelial carcinoma in association with surface low-grade papillary urothelial carcinoma: clinical and pathologic insights from a rare entity.

American journal of clinical pathology·2026

Same journal

CEACAM1 expression by immunohistochemistry in B-cell lymphomas and plasma cell myeloma.

American journal of clinical pathology·2026

Same journal

Comprehensive multicriteria life cycle assessment of biopsy processing in a surgical pathology department.

American journal of clinical pathology·2026

Same journal

Prognostic significance of Myb protein and its downstream target genes in lacrimal gland adenoid cystic carcinoma.

American journal of clinical pathology·2026

Same journal

Mismatch repair protein "nonclassic expression loss" pattern in colorectal cancer: an important staining pattern that is not well understood.

American journal of clinical pathology·2026

Same journal

Musculoskeletal pain in medical laboratory personnel: a cross-sectional study.

American journal of clinical pathology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 27, 2025

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Double-Hit and Triple-Hit Follicular Lymphoma.

Jessica B Ziemba¹, Zena Wolf¹, Matthew Weinstock²

¹Department of Pathology, Boston, MA.

American Journal of Clinical Pathology

|March 1, 2020

Summary

This summary is machine-generated.

Double-hit and triple-hit follicular lymphoma present with high stage disease and worse survival than classic follicular lymphoma. Aggressive therapy may improve outcomes, but further research is needed.

Keywords:

MYC rearrangement Follicular lymphoma Double hit Lymphoma Triple hit

More Related Videos

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Dec 27, 2025

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Published on: January 7, 2019

Area of Science:

Hematology
Oncology
Pathology

Background:

Follicular lymphoma (FL) is a common non-Hodgkin lymphoma.
MYC and BCL2/BCL6 rearrangements define aggressive subtypes of FL.
Characterizing these aggressive variants is crucial for treatment stratification.

Observation:

This study analyzed 3 cases and 37 published cases of FL with MYC and BCL2/BCL6 rearrangements.
Patients often presented with low-grade but advanced-stage disease.
Absence of B symptoms was common despite high-stage disease.

Findings:

Double-hit and triple-hit FL demonstrated poorer overall survival compared to classic FL.
The etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (EPOCH-R) regimen showed promising results in a small sample.
Aggressive pathologic features like angioinvasion and high proliferation index warrant MYC rearrangement testing.

Implications:

Double-hit and triple-hit FL may represent a distinct clinicopathologic entity.
Consideration of aggressive chemotherapy regimens, similar to those for high-grade B-cell lymphoma with MYC rearrangements, is warranted.
Further evidence is required to establish aggressive therapy as the standard of care for these aggressive FL subtypes.