Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

2.7K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.7K
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

4.3K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
4.3K
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

4.0K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
4.0K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

2.4K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
2.4K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

502
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
502
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

7.6K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endocrine Hypertension in Children and Adults: Beyond Primary Aldosteronism.

Advances in kidney disease and health·2026
Same author

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same author

Reprogramming of Iron and Oxygen Metabolism Across the Spectrum of Primary Aldosteronism.

medRxiv : the preprint server for health sciences·2026
Same author

Nonclassic congenital adrenal hyperplasia and bilateral pheochromocytomas in a patient with a germline pathogenic <i>MAX</i> variant.

JCEM case reports·2026
Same author

Evaluation and Management of Primary Aldosteronism.

Endocrinology and metabolism clinics of North America·2026
Same author

Dysregulated Aldosterone Production in Obesity Is Associated With Adverse Cardiac Structure, Function, and Adiposity.

Circulation·2026

Related Experiment Video

Updated: Dec 27, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

24.0K

Adrenocortical hyperplasia: A multifaceted disease.

Isabelle Bourdeau1, Stéfanie Parisien-La Salle1, André Lacroix1

  • 1Division of Endocrinology, Department of Medicine, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montréal, Canada.

Best Practice & Research. Clinical Endocrinology & Metabolism
|March 3, 2020
PubMed
Summary

Adrenocortical hyperplasia presents in various forms, impacting cortisol and aldosterone levels. Understanding these multifaceted conditions is crucial for diagnosing and managing related endocrine disorders.

Keywords:
Cushing's syndromeadrenocortical hyperplasiacongenital adrenal hyperplasiamicronodular adrenal hyperplasiaprimary bilateral macronodular adrenal hyperplasiaprimary pigmented nodular adrenal disease

More Related Videos

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

8.4K
Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands
08:37

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

Published on: October 2, 2018

25.0K

Related Experiment Videos

Last Updated: Dec 27, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

24.0K
Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

8.4K
Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands
08:37

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

Published on: October 2, 2018

25.0K

Area of Science:

  • Endocrinology
  • Adrenal Gland Physiology
  • Hormone Secretion Disorders

Background:

  • Adrenocortical hyperplasia is a complex condition with diverse etiologies.
  • It can manifest as primary bilateral macronodular adrenocortical hyperplasia (PBMAH) or micronodular bilateral adrenal hyperplasia (MiBAH), including PPNAD and i-MAD.
  • Secondary hyperplasia arises from chronic ACTH stimulation or enzymatic defects.

Purpose of the Study:

  • To review and discuss recent findings on the various forms of adrenocortical hyperplasia.
  • To elucidate the different contexts in which adrenocortical hyperplasia can develop.
  • To highlight the clinical implications of these diverse hyperplastic conditions.

Main Methods:

  • Literature review of recent findings on adrenocortical hyperplasia.
  • Synthesis of information on the classification and causes of adrenocortical hyperplasia.
  • Discussion of the hormonal consequences and associated syndromes.

Main Results:

  • Adrenocortical hyperplasia encompasses primary forms (PBMAH, MiBAH) and secondary forms due to ACTH stimulation or congenital defects.
  • Primary bilateral macronodular adrenocortical hyperplasia and micronodular bilateral adrenal hyperplasia can lead to cortisol oversecretion and Cushing's syndrome.
  • Idiopathic bilateral adrenal hyperplasia is a significant cause of primary aldosteronism.

Conclusions:

  • Adrenocortical hyperplasia is a multifaceted condition with varied presentations and underlying mechanisms.
  • Accurate classification and understanding of these forms are essential for appropriate patient management.
  • Further research into the pathophysiology of adrenocortical hyperplasia can improve diagnostic and therapeutic strategies.